I have a ASUS P8Z77V-PRO board and after I installed a PCI card for interfacing with a serial mouse, my onboard audio died.

I've reinstalled windows over itself (i have yet to do a fresh wipe install, that's next)
I've reset CMOS
I've updated BIOS before and then again after resetting CMOS
I've uninstalled my audio drivers and reinstalled them.

I still get audio with USB speakers (duh, I guess) but all my outputs are DEAD as doornails.

Looks like I'm going to RMA the board to ASUS since amazon *probably* won't take it back now, but it still sucks. I was hoping someone here had some experience loosing onboard audio, or with amazon returns (maybe I'll get a nice agent that will allow the RMA...)

Anyway...that's where I'm at. Major bummer for such a nice board.